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Remicade Infusion: What to Expect and How to Prepare

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Considering Remicade infusions? Discover how to prepare, what to expect, and what happens next.


It's common to have questions regarding the prescription of any new medication, especially an ongoing biologic infusion. How should you prepare? What should you expect? What happens next? 

If you're new to Remicade (infliximab) infusions, we've provided some pointers to help you prepare for your first infusion.

What is Remicade & what is it used to treat?

What is Remicade?
Remicade is the brand name for a monoclonal antibody (infliximab) used to treat several autoimmune diseases including Crohn’s disease, ulcerative colitis, rheumatoid arthritis (in combination with methotrexate), Ankylosing spondylitis, psoriatic arthritis, and plaque psoriasis.

How does Remicade work?
Remicade can help alleviate symptoms, induce and sustain remission, encourage intestinal healing, and reduce or eliminate the need for steroids. Individuals who take Remicade for inflammatory bowel disease (IBD) symptoms typically experience symptomatic relief or a period of inactivity in the disease process.

Remicade inhibits the action of a protein produced by the immune system known as tumor necrosis factor-alpha (TNF-alpha), which causes the immune system to attack healthy parts of the body. Those suffering from certain diseases may have too much TNF-alpha.

Rather than Remicade, your healthcare provider may prescribe an infliximab biosimilar such as Avsola, Inflectra, or Renflexis. According to the FDA, biosimilars have no clinically meaningful differences from their reference drug.

How is Remicade administered?
Your healthcare professional is responsible for supervising and guiding the administration of Remicade through intravenous (IV) infusion. The infusion process lasts for at least two hours and, after three induction doses, subsequent infusions occur at eight-week intervals.

Your Remicade dosage is determined by the severity of your illness, as well as your weight. During treatment, your healthcare provider will sterilize the area around your arm with rubbing alcohol. The needle will be inserted and taped in place. Then, the medication will be infused into your veins. 

During the infusion, your healthcare provider will check your vital signs at 30-minute intervals. The caregiver will also watch you closely throughout the infusion process. 

When you arrive at a Local Infusion center for your first Remicade infusion session, our team members greet you warmly and escort you to your private suite where you begin the two-hour process in comfort. 

What to do before your Remicade infusion

First, take a trip to your doctor’s office. Tell your doctor if:

  • You believe you have an infection. Remicade infusion is not recommended for people with infections as this can trigger the worsening of the infection.
  • You’re undergoing an infection treatment or have recurrent infections
  • There are sores or open cuts on your body
  • You’ve been diagnosed with diabetes or have an immune system disorder
  • You have tuberculosis (TB) or have been in close contact with someone who does
  • You live or have lived in an area where certain types of fungal infections such as blastomycosis are common
  • You've been diagnosed with Hepatitis B
  • You are pregnant or breastfeeding
  • You have heart failure
  • You use biologics (other medications that treat the same diseases Remicade does) such as Orencia (abatacept), Kineret (anakinra), or Actemra (tocilizumab)

Once your doctor has cleared you to use Remicade and provided a referral, you can proceed to book an infusion appointment. 

It's essential to get a good night's sleep, drink plenty of water, and eat something before receiving a Remicade infusion. A healthcare professional will conduct general health assessments and record your vitals, including your blood pressure, pulse, respiration, weight, and temperature. 

What to bring to your infusion session

On the day of your appointment, bring the following items:

  • Insurance card(s)
  • A means of identification
  • Relevant medical records
  • Current list of drugs you’re taking (to avoid drug interactions between Prednisone and Remicade, among others)

Since the infusion process lasts a couple of hours, you may need to take your smartphone, laptop, tablet, or book with you to pass the time. Or, if you’d prefer, you may decide to take a pillow with you and nap instead.

Also, it’s recommended to wear loose-fitting clothes and layers to prepare yourself for temperature changes.

Some other non-essentials you can take to your infusion therapy appointment include:

  • Warm socks or slippers
  • Eye mask
  • Earplugs or earbuds
  • Blankets
  • Water bottle
  • A book
  • An assistive device like a folding cane, in case you get drowsy or dizzy
  • Mint or gum
  • Snacks and drinks
  • Phone charger
  • Hat

What to expect after your infusion

Our healthcare providers will observe you for roughly two hours following the administration of Remicade or one of its biosimilars (Avsola, Inflectra, or Renflexis), to look out for any potential allergic reactions or side effects.

Acute (i.e. immediate) reactions that develop during treatment (and typically subside over time) may include fever/sweating, sinus infections, blood pressure variations, nausea, and itching. IBD patients who develop antibodies to infliximab have a higher risk of developing acute reactions.

Delayed reactions that develop within 3-12 days after infusion may include muscle/joint aches, lethargy, and rashes.

If you're worried about more serious (but rare) side effects such as weight gain, nervous system disorders, liver injury, lymphoma or skin cancer, please let your dedicated Infusion Guide know. We'd be happy to discuss further with you.

If you notice any of these signs, please report to your doctor or dedicated Infusion Guide immediately. 

Medications to prevent reactions

Select reactions to Remicade can be managed using meds. According to certain studies, the medications typically recommended for acute infusion reactions are epinephrine and diphenhydramine.

With mild reactions, physicians stop the infusion treatment and evaluate the patient for signs and symptoms of an acute reaction, in which case oral diphenhydramine is administered.

For moderate-to-severe reactions, the physician stops the infusion and immediately administers epinephrine and/or intravenous diphenhydramine. 

FAQs about Remicade infusion therapy

  1. What’s the success rate of Remicade treatment?

    Although individual results may vary, a one-year clinical study showed nearly six out of ten patients achieved response with Remicade after two weeks. Four out of ten patients achieved remission with Remicade compared to three out of ten who did not use Remicade infusion therapy.

    When using Remicade to treat chronic conditions, it’s essential to discuss your treatment goals with your doctor, whether it is symptom reduction or remission. 

  2. Can I drive after Remicade infusion? 

    This depends on whether or not you feel any side effects after your first session. If you feel fine after the first round of treatments, then you’ll be able to drive after future sessions. Joint pain, lethargy, and muscle aches — which are common after-effects of Remicade — may impede your driving abilities.

    It is safe to drive if you don’t feel any of these reactions, but best to verify from your doctor before doing so.

  3. How long can you stay on Remicade?

    Your medical professional will review how effective the treatment is for you from time to time to determine how long you should stay on the drug. If yours is a planned course of treatment, there will be a reassessment of your treatment every few months to see if it’s still fitting for you.

    Sometimes, the drug loses its effectiveness over time and your medical professional may need to increase your dosage or move you to another biologic drug.

  4. Will Remicade cause changes in my mood?

    It’s not likely. In clinical studies that have been conducted about the side effects of the drug, depression or mood changes were not listed.

  5. What drugs should not be taken with Remicade?

    There are certain types of medications to avoid when using this drug, including KINERET (anakinra), ORENCIA (abatacept), and ACTEMRA (tocilizumab) in combination with Remicade. Speak with your doctor about any type of drugs, vitamins, and supplements you may be taking as well.
  6. What are the active ingredients in Remicade?

    The active ingredient in the drug is infliximab, but there are many other inactive ingredients, including Dibasic sodium phosphate dihydrate, monobasic sodium phosphate monohydrate, polysorbate 80, and sucrose. There are no active or inactive preservatives in the drug.

How Local Infusion can help

If Remicade is part of your autoimmune disease treatment plan, then consider Local Infusion for your ongoing care. We make it possible to receive therapy in a modern, state-of-the-art center with private suites thoughtfully designed with your comfort in mind.

You also get a dedicated Infusion Guide to support you on your treatment journey every step of the way. Your guide is there to provide you with clear answers to any of your questions, including expectations for your first treatment session and how you can access financial support for your treatments.

READ MORE: Why Local Infusion

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